“Per- and polyfluoroalkyl substances induce cardiotoxicity and alter protein profiles of extracellular matrix, metabolism, and mitochondrial function in human cardiomyocytes”

HERCULES Investigators Drs. Wenhao Zhang, Michael Caudle, and Chunhui Xu recently had a manuscript accepted for publication in Chemical Research in Toxicology and their submitted cover art was selected as a Front Cover for a future issue. This study examined cardiotoxic effects of PFAS mixtures using human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) and found that combined exposure to three common PFAS compounds drive mitochondrial dysfunction, oxidative stress, metabolic changes, and ECM remodeling in hiPSC-CMs, underscoring the importance of evaluating PFAS mixtures to better understand cardiac risks from environmental exposure. Read the full paper here (link will be shared when it is available).