The HERCULES Integrated Health Sciences Facility Core (IHSFC); divided into Untargeted Exposure Analyses (Metabolomics), Targeted Exposure Analyses, and Research Services; along with the Environmental Health Data Sciences Core (EHDSC), provide the technical tools and services to support specific research activities of HERCULES investigators.
High Resolution Metabolomics
Dean Jones, PhD, IHSFC Director
Untargeted metabolomics is a standardized high-resolution protocol used to obtain a global view of metabolism and environmental exposures. The platform is suitable for use as a central reference for exposome research because of the expansive coverage (>20,000 chemical signals), including hundreds of know intermediary metabolites and a broad spectrum of environmental chemicals, food and microbiome-derived metabolites. High resolution metabolomics provides a central anchor for exposome research enabling generalized integration of multiple exposure metrics, measures of biologic response of an individual to exposures and metabolic changes consistent with disease pathophysiology to characterize environmental contributions to disease. More information on the Jones Lab may be found here.
Targeted Exposure Analysis
Dana Boyd Barr, PhD, IHSFC Co-Lead
A unique suite of multiple types of mass spectrometers allows for measurement of any chemical in multiple biological matrices. With state of the art analytical technologies and complementary scientific experience, assays can be developed to target specific research needs.
Clinical/Population Research Services
Carmen Marsit, PhD, IHSFC Co-Lead, Epidemiology/Populations
Miriam Vos, MD, IHSFC Co-Lead, Pediatric Populations
Tom Ziegler, MD, IHSFC Co-Lead, Clinical Subjects
This component of the IHSFC is designed to provide services to promote translation of basic science concepts into practical clinical and population research designs that can significantly promote incorporation of environmental health sciences (i.e., exposome research) into clinical medicine and population-based health research.
Environmental Health Data Sciences Core
Lance Waller, PhD, EHDSC Director, Biostatistics
Eberhard Voit, PhD, EHDSC Co-Director, Systems Biology
The EHDSC aims to expand and foster a data, analytic, and collaborative ecosystem for exposome-related research. The team has a strong body complementary expertise in mathematical modeling and systems biology, allowing personalized work with each investigator to assist in developing the best approach for their specific work.
Biostatistics and Bioinformatics
The Biostatistical Consulting Center serves as a resource for HERCULES investigators.